Longitudinal Assessment of Dynamics in T-cell Immunity Using HCV Infection as a Human Model System.

Hepatitis C virus (HCV) infection is an excellent model to study human immunology in the context of chronic viral infection due to its unique clinical features.

Cross-sectional and Prospective Study of Peripheral and Intrahepatic Immunity in Acute and Chronic Hepatitis B with or without Antiviral Treatment.

Hepatitis B virus (HBV) infection is a major public health problem despite successful prophylactic vaccines being readily available. While the infection resolves acutely in 95% of adults, the majority of infected children develop chronic disease. This is a major health burden, especially in countries with limited resources, low vaccination rates, and limited peri-partum care leading to high rates of perinatal transmission. Though hepatitis B therapy can suppress viremia and thereby control the virus in the chronic phase, clearance is not achieved with antivirals. Chronic hepatitis B (both treated and untreated) is associated with increased risk of cirrhosis and development of hepatocellular carcinoma (HCC).